Endocrine Abstracts

Prostate cancer (PCa) is one of the most common endocrine-related cancers (ERCs) among men worldwide. The aggressiveness of this tumor pathology is highly influenced by different endocrine-related factors, highlighting the crucial role of androgens. Therefore, the main therapeutic approach for PCa patients is based on the pharmacological blockade of androgen-signaling. However, some patients become unresponsive and develop a highly lethal castration-resistant disease, pointing...

Obesity is a chronic metabolic disease associated with important metabolic and inflammatory comorbidities, which can be reversed or improved after bariatric-surgery (BS). However, some underlying mechanisms, independent of weight-loss, are still unknown. In this context, dysregulations in the inflammasome, a multiproteic complex that promotes cytokine maturation and induces cellular pyroptosis, has been associated to the development/stage of some cancer-types and obesity. Howe...

Pituitary tumours (PTs) constitute approximately 15% of all brain tumours, affecting up to 5% of the general population. The majority of PTs are hormonally active tumours (approximately 70%), resulting in significant comorbidities associated with hormone release. Furthermore, clinically non-functioning PTs (NFPTs, around 30%) exhibit mass effect-related comorbidities due to delayed diagnosis, despite lacking a link to hormone excess. Recent studies indicate that aberrant alter...